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Sclerostin antibody treatment enhances metaphyseal bone healing in rats. Agholme F(1), Li X, Isaksson H, Ke HZ, Aspenberg P. Author information: (1)Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, Linköping, Sweden. email@example.com Sclerostin is the product of the SOST gene. Sclerostin antibody (Scl‐Ab) increases osteoblast activity, in part through increasing modeling‐based bone formation on previously quiescent surfaces.
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Six-month-old male SD Sclerostin-antibody Introduction Patients treated chronically with glucocorticoids (GCs) have decreased bone formation and increased bone resorption and fragility [1, 2]. The mechanisms that account for GC-induced W. Yao and W. Dai contributed equally to this work. Electronic supplementary material The online version of this article 2013-04-29 · Antibodies against Sclerostin were generated from the HuCAL GOLD antibody library using recombinant murine Sclerostin in a solution panning (T.D. Mueller et al., manuscript in preparation). The Fab antibodies showing the best binding to Sclerostin were tested to see if they had an effect on binding of Sclerostin-GFP to 293 cells over-expressing LRP6. Antibodies against SOST/Sclerostin are validated for multiple applications,including ELISA.
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SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. Cerberus/DAN family members are putative BMP antagonists, and include Dan, Cerberus, Gremlin, PRDC, and Caronte. 2020-10-01 · Sclerostin antibodies have also been investigated preclinically for other bone loss and bone injury settings.
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The company’s work on bone health treatments is of interest to NASA as it continues to explore ways to protect astronauts’ health in space, but the research has benefits for people suffering from osteoporosis here on Earth. sclerostin antibody nor zoledronic acid improved biomechanical properties in the animals.
This investigational monoclonal antibody, and blosozumab, another investigational anti-sclerostin antibody, have osteoanabolic properties with the potential to improve clinical outcomes in patients with osteoporosis. Sclerostin Antibodies Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. 2017-08-29 · Sclerostin is an osteocyte-derived glycoprotein that inhibits Wnt/β-catenin signaling and activation of osteoblast function, thereby inhibiting bone formation.
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 inhibition of sclerostin by monoclonal antibodies induces osteoblast activity and new bone formation, normalizing bone mass and improving bone architecture and strength. In recently completed clinical trials, anti-sclerostin antibody therapy results in marked increases in bone mineral density and rapid and substantial reduction in fracture risk. Sclerostin is a Wnt signaling antagonist and acts as a negative regulator for bone formation.
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It enhances bone formation and simultaneously 8 Jan 2018 Abstract.